A lot changed between late 2025 and spring 2026. Some household telehealth names pulled back from compounded semaglutide, regulators put more pressure on sloppy marketing, and LillyDirect added a lower-priced oral pathway that changed the comparison.
What follows is a look at six providers that have enough transparency, pricing clarity, or clinical structure to actually be worth your time.
1. HealthRX
Best for: Cash-pay patients who want low entry pricing, a named pharmacy, and fast turnaround
HealthRX keeps its model simple. You fill out a health assessment online, a US board-certified physician reviews it within about 24 hours, and medication ships overnight to all 50 states for free. There are no hidden fees and no surprise charges once you are in.
Pricing is among the lowest posted anywhere in this category. Compounded semaglutide starts at $99 per month. Compounded tirzepatide starts at $149 per month. Both are once-weekly injections.
What separates HealthRX from the many compounding telehealth brands that keep their supply chain vague: the medication is dispensed by Manifest Pharmacy in Greer, South Carolina, a 503A compounding pharmacy that operates under USP-797 standards with lot-tracked batch control from production to delivery. The platform carries LegitScript certification (certificate number 50087439), which requires ongoing compliance review and is not automatic. HIPAA compliance is standard.
The efficacy numbers HealthRX references come from published trials, not internal claims. Tirzepatide produced roughly 21% body weight reduction at 72 weeks in SURMOUNT-1. Semaglutide produced roughly 15% at 68 weeks in STEP 1. These are compounded medications and are not FDA-approved products.
Verdict: Strongest combination of price, shipping speed, pharmacy transparency, and 50-state access in this group. The right pick for most cash-pay patients starting out.
2. FormBlends
Best for: Patients who want published purity documentation, or who also want peptides for recovery or cognition
FormBlends runs a compounded GLP-1 program with physician oversight and fills through an FDA-registered 503A compounding pharmacy. The thing that makes it stand out from most telehealth options is the testing data it actually publishes: HPLC purity percentages, mass spectrometry identity confirmation, endotoxin levels, and sterility results are listed per product by name. Most platforms in this category do not do that.
It ships to 47 states, which is slightly more limited than HealthRX’s full 50-state reach. Pricing runs higher too: compounded semaglutide is around $299 per vial, tirzepatide around $349. If price is your primary filter, this is not the winner.
Where FormBlends pulls ahead is breadth. The same clinician-reviewed model covers a full peptide catalog, including options for recovery, longevity, and cognitive support. Most GLP-1-only telehealth brands offer nothing outside that lane. If you want one provider for multiple peptide goals, FormBlends is the only option on this list that supports that.
Verdict: Higher price point than HealthRX, but worth it if published purity testing matters to you or if you want GLP-1 treatment alongside other peptides under one roof.
3. Mochi Health
Verdict: One of the few telehealth platforms staffed specifically by board-certified obesity medicine clinicians rather than general practitioners. Compounded semaglutide is around $99 per month, tirzepatide around $199. The clinical oversight is more thorough than most, which means slightly more friction but also more monitoring. Good fit for patients with complex histories.
4. Hims & Hers
Verdict: After exiting compounded semaglutide following the March 2026 Novo settlement, Hims & Hers moved to branded medications. Injectable Wegovy runs around $299 per month, oral options around $249, and Zepbound around $399. With insurance and a savings card, costs can drop to $0 to $25. This is the platform for someone who wants branded meds and strong insurance coordination, not the cheapest compounded option.
5. Ro Body
Verdict: Ro charges roughly $39 for the first month, then $74 to $149 per month for the membership, with medications billed separately. The prior authorization team is a genuine asset for anyone attempting to get insurance to cover branded GLP-1s. Takes insurance for branded prescriptions. Works well for patients who are motivated to push through the insurance process rather than paying cash.
6. PlushCare
Verdict: Membership is about $19.99 per month, one of the lowest platform fees on this list. PlushCare focuses on branded medications and accepts insurance. Same-day appointments are available in many cases. It is not a GLP-1-specialty clinic the way Mochi or Form Health are, but for someone who already has insurance coverage and wants low overhead on the telehealth side, it earns its place here.
A note before making any decision: compounded GLP-1 medications are not FDA-approved drugs. They are legally prepared copies produced by licensed compounding pharmacies. Speak with your own physician about whether any of these options fit your health situation.
Common Questions
Is compounded semaglutide from HealthRX or FormBlends the same drug as branded Ozempic or Wegovy?
No. Compounded semaglutide is a legally prepared copy made by a licensed 503A pharmacy, not an FDA-approved product. The active molecule is the same, but branded drugs go through FDA’s full approval process. Compounded versions have not, which is worth understanding before you start either program.
After the March 2026 Novo settlement, can any of these platforms still prescribe compounded semaglutide?
Some can. Hims & Hers stopped. HealthRX and FormBlends continued through licensed 503A compounding pharmacies, which can still legally prepare compounded semaglutide under certain conditions. The regulatory picture keeps shifting, so confirming availability directly with any platform before signing up is the right move.
Which of these clinics makes the most sense if my insurance already covers Wegovy or Zepbound?
Hims & Hers, Ro Body, and PlushCare are the strongest fits. All three accept insurance for branded prescriptions. Ro has a dedicated prior authorization team, which matters if your insurer requires that step. PlushCare has the lowest platform fee at $19.99 per month, so overhead stays minimal if insurance is doing the heavy lifting.
What does LegitScript certification actually mean for a telehealth clinic like HealthRX?
LegitScript is an independent compliance organization. Certification requires a clinic to meet standards around prescription practices, pharmacy sourcing, and advertising, and it involves ongoing review rather than a one-time check. It does not guarantee outcomes, but it does mean the platform passed scrutiny that many telehealth operators quietly avoid.
Does Mochi Health’s obesity medicine specialty actually change the clinical experience compared to a general telehealth platform?
In practice, yes. Board-certified obesity medicine physicians are trained specifically in weight physiology, medication titration, and managing comorbidities like type 2 diabetes alongside GLP-1 therapy. A general practitioner can prescribe these drugs, but Mochi’s specialist model means the clinical review is more likely to catch nuances that matter for patients with complicated histories.
Sources
- FDA warning letters to telehealth and compounding firms, January-March 2026 (FDA.gov enforcement announcements)
- Novo Nordisk settlement and impact on compounded semaglutide, March 9 2026 (Novo Nordisk press release; Reuters)
- SURMOUNT-1 trial: tirzepatide efficacy data, *New England Journal of Medicine*, 2022
- STEP 1 trial: semaglutide efficacy data, *New England Journal of Medicine*, 2021
- LegitScript certification database (LegitScript.com)
- Lilly orforglipron pricing and LillyDirect launch, April 2026 (Eli Lilly press release)
